- Molecular Biology
- Viral Vectors & Cell Engineering
- Protein Engineering & Production
- Antibody Discovery & Engineering
- Antibody Production
-
Analytics & Formulation
- Overview
- Purity Analysis by CE-SDS
- Aggregation Analysis
- Charge Variant Analysis
- De Novo Antibody Sequencing
- Intact Mass Analysis
- Sequence Confirmation by Mass Spectrometry
- N-terminal Sequencing
- Post-Translational Modification
- N-glycan Analysis
- Thermostability Analysis
- Stability Analysis
- Formulation Development
- Developability Analysis
- FAQs
- R&D and cGxP Bioassay Development
- Protein Chemistry
- Development & Manufacturing in LakePharma Hayward, CA
- Development & Manufacturing in LakePharma Hopkinton, MA
- Consulting Services
CHO Stable Cell Line Development
LakePharma provides stable CHO cell line development services for diagnostic or therapeutic products.
Developed from the CHO-K1 parental cell line, LakePharma offers the CHO-GSN™ stable cell line expression platform for the production of proteins and antibodies. CHO-GSN™ is a glutamine synthetase (GS) knockout cell line for the generation of a research cell bank (RCB) and future use as a manufacturing cell line for commercial products. With multiple RCBs used for programs at the clinical stage, this platform offers clients a cell line with lineage documentation and a commercial use license for commercialization (royalty-free option available).
LakePharma provides the CHO-GSN™ platform as a CHO stable cell line development service using its proprietary knockout cell line, custom stable expression vectors, and glutamine synthetase (GS) selection technology platform.
| Download CHO-GSN™ Presentation by clicking here. |
As a service, RCBs are generated under the following workflow:
After the RCB is developed, LakePharma also offers characterization services, MCB generation, and process development services:
